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In vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii.

Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus , Coccidioides , Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifu...

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Published in:Revista Iberoamericana de Micologia Vol. 36; no. 3; pp. 139 - 142
Main Authors: Villanueva-Lozano, Hiram, Treviño-Rangel, Rogelio de J., Téllez-Marroquín, Ricardo, Bonifaz, Alexandro, Rojas, Olga C., Hernández-Rodríguez, Pedro A., González, Gloria M.
Format: Article
Published: Elsevier B.V. Jul2019
Subjects:
Antifungal agents
Itraconazole
Sporotrichosis
Amphotericin B
Drug interactions
Sertraline
Trichosporon
Online Access:View this record in EBSCOhost
Summary:Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus , Coccidioides , Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifungals. In our study we evaluate the antifungal activity of SRT, alone and in combination with itraconazole (ITC), voriconazole (VRC) and amphotericin B (AMB), against 15 clinical isolates of Sporothrix schenckii. We used the broth microdilution method as described by the CLSI to test the susceptibility to antifungals, and the checkerboard microdilution method to evaluate drug interactions. The minimum inhibitory concentration (MIC) with SRT was in the range of 4–8 μg/ml, while for AMB, VRC and ITC were 0.5–4 μg/ml, 0.5–8 μg/ml and 0.125–2 μg/ml, respectively. In addition, SRT showed synergy with ITC in one strain, mainly additivity with VRC, and indifference with AMB in others. The MIC values with SRT for the isolates studied show the potential role of this drug as an adjuvant in the treatment of sporotrichosis, especially in disseminated or complicated cases.
La sertralina (SRT) es un antidepresivo que ha demostrado actividad in vitro contra Cryptococcus , Coccidioides , Trichosporon y otros hongos. La esporotricosis diseminada, aunque rara, tiene una mortalidad elevada y su tratamiento es complicado, requiriendo, a menudo, la combinación de dos o más antifúngicos. En este estudio evaluamos la actividad antifúngica de SRT, sola y en combinación con itraconazol (ITC), voriconazol (VRC) y anfotericina B (AMB), frente a 15 aislamientos clínicos de Sporothrix schenckii. Se usó la técnica de microdilución en caldo para evaluar la sensibilidad a los antifúngicos y el método de tablero de damas para las interacciones entre estos fármacos. La concentración mínima inhibitoria (CMI) de SRT estuvo en el rango de 4-8 μg/ml, mientras que para AMB, VRC e ITC fue de 0,5–4 μg/ml, 0,5–8 μg/ml y 0,125–2 μg/ml, respectivamente. La SRT mostró sinergia con ITC frente a una cepa, efecto aditivo principalmente con VRC, e indiferencia con AMB. Los valores de la CMI de SRT para los aislamientos ensayados son indicativos del potencial de este fármaco como adyuvante en el tratamiento de la esporotricosis, especialmente en casos complicados o de enfermedad diseminada.