Differential rearing alters taste reactivity to ethanol, sucrose, and quinine.
Rationale: Early-life environment influences reinforcer and drug motivation in adulthood; however, the impact on specific components of motivation, including hedonic value ("liking"), remains unknown. Objectives: The current study determined whether differential rearing alters liking and aversive re...
| Publicado en: | Psychopharmacology Vol. 237; no. 2; pp. 583 - 598 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141727146&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141727146 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Feb2020 vid: 237 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141727146 10.1007/s00213-019-05394-x 141727146 ppf: 583 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Differential rearing alters taste reactivity to ethanol, sucrose, and quinine. aug: au: Wukitsch, Thomas J. Brase, Emma C. Moser, Theodore J. Kiefer, Stephen W. Cain, Mary E. affil: Department of Psychological Sciences, Kansas State University, 492 Bluemont Hall, 1114 Mid-Campus Dr N, 66506-5302, Manhattan, KS, USA sug: ab: Rationale: Early-life environment influences reinforcer and drug motivation in adulthood; however, the impact on specific components of motivation, including hedonic value ("liking"), remains unknown. Objectives: The current study determined whether differential rearing alters liking and aversive responding to ethanol, sucrose, and quinine in an ethanol-naïve rat model. Methods: Male and female rats were reared for 30 days starting at postnatal day 21 in either an enriched (EC), isolated (IC), or standard condition (SC). Thereafter, all rats had indwelling intraoral fistulae implanted and their taste reactivity to water, ethanol (5, 10, 20, 30, 40% v/v), sucrose (0.1, 0.25, 0.5 M), and quinine (0.1, 0.5 mM) was recorded and analyzed. Results: EC rats had higher amounts of liking responses to ethanol, sucrose, and quinine and higher amounts of aversive responses to ethanol and quinine compared to IC rats. While EC and IC rats' responses were different from each other, they both tended to be similar to SCs, who fell in between the EC and IC groups. Conclusions: These results suggest that environmental enrichment may enhance sensitivity to a variety of tastants, thereby enhancing liking, while isolation may dull sensitivity, thereby dulling liking. Altogether, the evidence suggests that isolated rats have a shift in the allostatic set-point which may, in part, drive increased responding for a variety of rewards including ethanol and sucrose. Enriched rats have enhanced liking of both sucrose and ethanol suggesting that enrichment may offer a unique phenotype with divergent preferences for incentive motivation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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