Initial dose optimization of tacrolimus for children with systemic lupus erythematosus based on the CYP3A5 polymorphism and coadministration with Wuzhi capsule.

What is known and objectives: Tacrolimus, an immunosuppressant, has been used to treat paediatric systemic lupus erythematosus, but the optimal initial regimen is not clear. The purpose of this study was to explore the optimal initial dose of tacrolimus for children with systemic lupus erythematosus...

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Bibliographic Details
Published in:Journal of Clinical Pharmacy & Therapeutics Vol. 45; no. 2; pp. 309 - 318
Main Authors: Chen, Xiao, Wang, Dongdong, Xu, Hong, Li, Zhiping
Format: equations & formulas research tables/charts Journal Article
Published: Wiley-Blackwell Apr2020
Online Access:View this record in EBSCOhost