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MRI-biochemical follow up measurements of lumbar intervertebral disc in patients with leg length discrepancy: Is it possible to alter cartilage damage with conservative therapy?

Objective: Effect of conservative therapy on intervertebral discs (IVD) in patients with leg-length-discrepancy (LLD). M&M: Seventy lumbar IVDs of 14 participants (five with LLD 10-20 mm) were examined using a 3T-MRI-scanner. Morphological (Pfirrmann) and molecular (glycosaminoglycan-chemical-exchan...

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Publicado en:Journal of Orthopaedics Vol. 16; no. 6; pp. 473 - 478
Autores principales: Frenken, Miriam, Latz, David, Schiffner, Erik, Quante, Wolfgang Alois, Knautz, Maxime, Abrar, Daniel Benjamin, Schaarschmidt, Benedikt, Schleich, Christoph
Formato: diagnostic images research tables/charts Journal Article
Publicado: Professor PK Surendran Memorial Education Foundation Nov/Dec2019
Acceso en línea:Ver este registro en EBSCOhost
Sumario:Objective: Effect of conservative therapy on intervertebral discs (IVD) in patients with leg-length-discrepancy (LLD). M&M: Seventy lumbar IVDs of 14 participants (five with LLD 10-20 mm) were examined using a 3T-MRI-scanner. Morphological (Pfirrmann) and molecular (glycosaminoglycan-chemical-exchange-saturation-transfer, gagCEST) grading was assessed before and after a four-month therapy (physiotherapy and shoe inlays). Results: Significantly lower GAG values in patients with LLD were found (L5/S1, p=0.02). After therapy, a trend towards higher gagCEST values in patients with LLD was observed (2.48 ± 1.77% vs. 1.79 ± 0.79%; p > 0.05). Conclusion: LLD represents a risk factor for molecular alterations of lumbar IVDs. Only minor effects of conservative therapy on these alterations could be found.