Influences of ABC transporter and CYP3A4/5 genetic polymorphisms on the pharmacokinetics of lenvatinib in Chinese healthy subjects.

Purpose: To investigate whether the CYP3A4/5 and ABC transporter genetic polymorphisms could affect the pharmacokinetics of lenvatinib in Chinese healthy subjects. Methods: Thirty-two healthy Chinese volunteers were enrolled and took oral administration of 8 mg lenvatinib. Plasma concentration of le...

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Publicado en:	European Journal of Clinical Pharmacology Vol. 76; no. 8; pp. 1125 - 1134
Autores principales:	Li, Jiaming, Wang, Xiaoqian, Ning, Chen, Wang, Zhaoyu, Wang, Yao, Zheng, Ming, Zhang, Siliang, Lu, Yang, Zhang, Yongjie, Li, Ning, Chen, Xijing, Zhao, Di
Formato:	research tables/charts Journal Article
Publicado:	Springer Nature Aug2020
Acceso en línea:	Ver este registro en EBSCOhost