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Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder.

Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV...

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Publicado en:Journal of Autism & Developmental Disorders Vol. 50; no. 8; pp. 2874 - 2886
Autores principales: Constable, Paul A., Ritvo, Edward R., Ritvo, Ariella R., Lee, Irene O., McNair, Morgan L., Stahl, Dylan, Sowden, Jane, Quinn, Stephen, Skuse, David H., Thompson, Dorothy A., McPartland, James C.
Formato: pictorial research tables/charts tracings Journal Article
Publicado: Springer Nature Aug2020
Acceso en línea:Ver este registro en EBSCOhost
Sumario:Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD.