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Mechanism of Ti-Catalyzed Oxidative Nitrene Transfer in [2 + 2 + 1] Pyrrole Synthesis from Alkynes and Azobenzene.

A combined computational and experimental study on the mechanism of Ti-catalyzed formal [2 + 2 + 1] pyrrole synthesis from alkynes and aryl diazenes is reported. This reaction proceeds through a formally Ti/Ti redox catalytic cycle as determined by natural bond orbital (NBO) and intrinsic bond orbit...

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Published in:Journal of the American Chemical Society Vol. 140; no. 23; pp. 7267 - 7282
Main Authors: Davis-Gilbert, Zachary W., Xuelan Wen, Goodpaster, Jason D., Tonks, Ian A.
Format: Article
Published: American Chemical Society 6/13/2018
Online Access:View this record in EBSCOhost
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      dt: 6/13/2018
      vid: 140
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      pub: American Chemical Society
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        10.1021/jacs.8b03546
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        atl: Mechanism of Ti-Catalyzed Oxidative Nitrene Transfer in [2 + 2 + 1] Pyrrole Synthesis from Alkynes and Azobenzene.
      aug:
        au:
          Davis-Gilbert, Zachary W.
          Xuelan Wen
          Goodpaster, Jason D.
          Tonks, Ian A.
        affil: Department of Chemistry, University of Minnesota − Twin Cities, Minneapolis, Minnesota 55455, United States.
      sug:
      ab: A combined computational and experimental study on the mechanism of Ti-catalyzed formal [2 + 2 + 1] pyrrole synthesis from alkynes and aryl diazenes is reported. This reaction proceeds through a formally Ti/Ti redox catalytic cycle as determined by natural bond orbital (NBO) and intrinsic bond orbital (IBO) analysis. Kinetic analysis of the reaction of internal alkynes with azobenzene reveals a complex equilibrium involving Ti═NPh monomer/dimer equilibrium and Ti═NPh + alkyne [2 + 2] cycloaddition equilibrium along with azobenzene and pyridine inhibition equilibria prior to rate-determining second alkyne insertion. Computations support this kinetic analysis, provide insights into the structure of the active species in catalysis and the roles of solvent, and provide a new mechanism for regeneration of the Ti imido catalyst via disproportionation. Reductive elimination from a 6-membered azatitanacyclohexadiene species to generate pyrrole-bound Ti is surprisingly facile and occurs through a unique electrocyclic reductive elimination pathway similar to a Nazarov cyclization. The resulting Ti species are stabilized through backbonding into the Ï€* of the pyrrole framework, although solvent effects also significantly stabilize free Ti species that are required for pyrrole loss and catalytic turnover. Further computational and kinetic analysis reveals that in complex reactions with unysmmetric alkynes the resulting pyrrole regioselectivity is driven primarily by steric effects for terminal alkynes and inductive effects for internal alkynes.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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          year: 2018
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