FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages.
FTY720 is a treatment for relapsing remitting multiple sclerosis (MS). It is an analog of sphingosine-1-phosphate (S1P) and targets S1P receptors 1, 3, 4, and 5. Recent reports indicate an association between long-term exposure to FTY720 and cases of cryptococcal infection. Here, we studied the effe...
| Publicado en: | Journal of Clinical Investigation Vol. 130; no. 9; pp. 4546 - 4561 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
American Society for Clinical Investigation
Sep2020
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| Acceso en línea: | Ver este registro en EBSCOhost |