Effectiveness of a decontamination procedure in a pharmacy buffer room contaminated by 5 antineoplastic agents.
Purpose Healthcare facilities are obligated to implement strategies to protect healthcare workers from exposure to hazardous drugs, including any real or potential risk from contaminated surfaces. Guidelines are broad and lack sufficient detail for healthcare facilities to establish clear effectiven...
| Publicado en: | American Journal of Health-System Pharmacy Vol. 77; no. 24; pp. 2081 - 2089 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
12/15/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=147400773&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 147400773 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10792082 1X3 jtl: American Journal of Health-System Pharmacy issn: 10792082 maglogo: N pubinfo: dt: 12/15/2020 vid: 77 iid: 24 pid: 622 pub: Oxford University Press / USA artinfo: ui: 147400773 147400773 147400773 10.1093/ajhp/zxaa320 147400773 ppf: 2081 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effectiveness of a decontamination procedure in a pharmacy buffer room contaminated by 5 antineoplastic agents. aug: au: Arpino, Paul Yeomelakis, Jason Oommen, Anisha affil: Department of Pharmacy, Mount Auburn Hospital , Cambridge MA sug: subj: Antineoplastic Agents Sterilization and Disinfection Methods Drug Contamination Occupational Exposure Decontamination, Hazardous Materials Human Pharmacy Service Drug Compounding Pharmacists Hazardous Materials Equipment Contamination Environmental Monitoring Fluorouracil Paclitaxel Doxorubicin Carboplatin Cyclophosphamide ab: Purpose Healthcare facilities are obligated to implement strategies to protect healthcare workers from exposure to hazardous drugs, including any real or potential risk from contaminated surfaces. Guidelines are broad and lack sufficient detail for healthcare facilities to establish clear effectiveness targets for their decontamination procedures. Our goal in this analysis was to measure the effectiveness of a decontamination procedure in a pharmacy buffer room contaminated with 5 antineoplastic drugs. Methods Six rounds of contamination, decontamination, and wipe sampling were performed in a pharmacy buffer room designated for hazardous drug (HD) compounding. Ten locations in the buffer room were contaminated with 5-fluorouracil, carboplatin, cyclophosphamide, paclitaxel, and doxorubicin. Pharmacy staff were blinded to contamination sites. After contamination, 3 pharmacy technicians following the same decontamination procedure decontaminated the buffer room. To assess the impact of decontamination, residual hazardous drug levels were assessed after contamination and after decontamination using a commercially available wipe sampling product. Results The mean (SD) residual contamination levels for the 239 wipe samples taken before and after decontamination were 63 (60) ng and 3.9 (8.2) ng, respectively, representing a 94% reduction in residual HD contamination. Residual contamination was not detectable (<5 ng) in 221 (~93%) of the samples after decontamination. Conclusion The employed decontamination procedures effectively reduced residual HD surface contamination. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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