Disrupted parahippocampal and midbrain function underlie slower verbal learning in adolescent-onset regular cannabis use.
Rationale: Prolonged use of cannabis, the most widely used illicit drug worldwide, has been consistently associated with impairment in memory and verbal learning. Although the neurophysiological underpinnings of these impairments have been investigated previously using functional magnetic resonance...
| Publicado en: | Psychopharmacology Vol. 238; no. 5; pp. 1315 - 1332 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=149947557&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 149947557 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: May2021 vid: 238 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 149947557 10.1007/s00213-019-05407-9 149947557 ppf: 1315 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Disrupted parahippocampal and midbrain function underlie slower verbal learning in adolescent-onset regular cannabis use. aug: au: Blest-Hopley, Grace O'Neill, Aisling Wilson, Robin Giampietro, Vincent Bhattacharyya, Sagnik affil: Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, SE5 8AF, London, UK sug: ab: Rationale: Prolonged use of cannabis, the most widely used illicit drug worldwide, has been consistently associated with impairment in memory and verbal learning. Although the neurophysiological underpinnings of these impairments have been investigated previously using functional magnetic resonance imaging (fMRI), while performing memory tasks, the results of these studies have been inconsistent and no clear picture has emerged yet. Furthermore, no previous studies have investigated trial-by-trial learning. Objectives: We aimed to investigate the neural underpinnings of impaired verbal learning in cannabis users as estimated over repeated learning trials. Methods: We studied 21 adolescent-onset regular cannabis users and 21 non-users using fMRI performed at least 12 h after last cannabis use, while they performed a paired associate verbal learning task that allowed us to examine trial-by-trial learning. Brain activation during repeated verbal encoding and recall conditions of the task was indexed using the blood oxygen level-dependent haemodynamic response fMRI signal. Results: There was a significant improvement in recall score over repeated trials indicating learning occurring across the two groups of participants. However, learning was significantly slower in cannabis users compared to non-users (p = 0.032, partial eta-squared = 0.108). While learning verbal stimuli over repeated encoding blocks, non-users displayed progressive increase in recruitment of the midbrain, parahippocampal gyrus and thalamus (p = 0.00939, partial eta-squared = 0.180). In contrast, cannabis users displayed a greater but disrupted activation pattern in these regions, which showed a stronger correlation with new word-pairs learnt over the same blocks in cannabis users than in non-users. Conclusions: These results suggest that disrupted medial temporal and midbrain function underlie slower learning in adolescent-onset cannabis users. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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