Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas.

Purpose: Epidermal growth factor receptor (EGFR) amplification promotes gliomagenesis and is linked to lack of oxygen within the tumor microenvironment. Using hypoxia-sensitive spin-and-gradient echo echo-planar imaging and perfusion MRI, we investigated the influence of EGFR amplification on tissue...

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Bibliographic Details

Published in:	Neuroradiology Vol. 63; no. 6; pp. 857 - 869
Main Authors:	Oughourlian, Talia C., Yao, Jingwen, Hagiwara, Akifumi, Nathanson, David A., Raymond, Catalina, Pope, Whitney B., Salamon, Noriko, Lai, Albert, Ji, Matthew, Nghiemphu, Phioanh L., Liau, Linda M., Cloughesy, Timothy F., Ellingson, Benjamin M.
Format:	diagnostic images pictorial research tables/charts Journal Article
Published:	Springer Nature Jun2021
Online Access:	View this record in EBSCOhost