Metabolic programming of nephron progenitor cell fate.

Metabolic pathways are one of the first responses at the cellular level to maternal/fetal interface stressors. Studies have revealed the previously unrecognized contributions of intermediary metabolism to developmental programs. Here, we provide an overview of cellular metabolic pathways and the cue...

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Publicado en:Pediatric Nephrology Vol. 36; no. 8; pp. 2155 - 2165
Autores principales: Tortelote, Giovane G, Colón-Leyva, Mariel, Saifudeen, Zubaida
Formato: review tables/charts Journal Article
Publicado: Springer Nature Aug2021
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2021
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      pub: Springer Nature
      place: New York, New York
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          Tortelote, Giovane G
          Colón-Leyva, Mariel
          Saifudeen, Zubaida
        affil: Department of Pediatrics, Tulane University School of Medicine, 1430 Tulane Avenue SL37, Room 5534, 70112, New Orleans, LA, USA
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        subj:
          Metabolic Networks and Pathways
          Nephrons Metabolism
          Stem Cells Metabolism
          Metabolites
          Epigenomics
          Proteomics
          Fetal Development
          Kidney Embryology
          Glycolysis
          Energy Metabolism
          Phosphorylation
      ab: Metabolic pathways are one of the first responses at the cellular level to maternal/fetal interface stressors. Studies have revealed the previously unrecognized contributions of intermediary metabolism to developmental programs. Here, we provide an overview of cellular metabolic pathways and the cues that modulate metabolic states. We discuss the developmental and physiological implications of metabolic reprogramming and the key role of metabolites in epigenetic and epiproteomic modifications during embryonic development and with respect to kidney development and nephrogenesis.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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