Metabolic programming of nephron progenitor cell fate.
Metabolic pathways are one of the first responses at the cellular level to maternal/fetal interface stressors. Studies have revealed the previously unrecognized contributions of intermediary metabolism to developmental programs. Here, we provide an overview of cellular metabolic pathways and the cue...
| Published in: | Pediatric Nephrology Vol. 36; no. 8; pp. 2155 - 2165 |
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| Main Authors: | , , |
| Format: | review tables/charts Journal Article |
| Published: |
Springer Nature
Aug2021
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| Online Access: | View this record in EBSCOhost |
| Summary: | Metabolic pathways are one of the first responses at the cellular level to maternal/fetal interface stressors. Studies have revealed the previously unrecognized contributions of intermediary metabolism to developmental programs. Here, we provide an overview of cellular metabolic pathways and the cues that modulate metabolic states. We discuss the developmental and physiological implications of metabolic reprogramming and the key role of metabolites in epigenetic and epiproteomic modifications during embryonic development and with respect to kidney development and nephrogenesis. |
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