New dihydrobenzofuranoid from the marine-derived fungus Aspergillus ustus KMM 4664.

One new dihydrobenzofuran derivative (1), known depsipeptide emericellamide A (2), three known drimanes (3–5) and two artifact drimane derivatives (6, 7) were isolated from the marine-derived fungus Aspergillus ustus KMM 4664. Their structures were determined by detailed analysis of spectroscopic da...

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Detalles Bibliográficos
Publicado en:Natural Product Research Vol. 35; no. 19; pp. 3332 - 3336
Autores principales: Oleinikova, Galina K., Zhuravleva, Olesya I., Berdyshev, Dmitrii V., Menzorova, Natalia I., Popov, Roman S., Denisenko, Vladimir A., Kirichuk, Natalya N., Afiyatullov, Shamil Sh.
Formato: Journal Article
Publicado: Taylor & Francis Ltd Oct2021
Acceso en línea:Ver este registro en EBSCOhost
Descripción
Sumario:One new dihydrobenzofuran derivative (1), known depsipeptide emericellamide A (2), three known drimanes (3–5) and two artifact drimane derivatives (6, 7) were isolated from the marine-derived fungus Aspergillus ustus KMM 4664. Their structures were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configuration of 1 was determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 7 showed significant ability of the inhibition of spermatozoa to fertilize egg-cells of the sea urchin Strongylocentrotus intermedius with IC50 value 21 µM.