Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis.

Objectives: Systemic sclerosis (SSc) is a complex disease of unknown aetiology in which inflammation and fibrosis lead to multiple organ damage. There is currently no effective therapy that can halt the progression of fibrosis or reverse it, thus studies that provide novel insights into disease path...

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Bibliographic Details

Published in:	Annals of the Rheumatic Diseases Vol. 81; no. 2; pp. 268 - 278
Main Authors:	Malaab, Maya, Renaud, Ludivine, Takamura, Naoko, Zimmerman, Kip D., da Silveira, Willian A., Ramos, Paula S., Haddad, Sandra, Peters-Golden, Marc, Penke, Loka R., Wolf, Bethany, Hardiman, Gary, Langefeld, Carl D., Medsger, Thomas A., Feghali-Bostwick, Carol A.
Format:	research Journal Article
Published:	Elsevier B.V. Feb2022
Online Access:	View this record in EBSCOhost