Pathergy: a review of potential mechanisms and novel therapeutic targets.
Pathergy reaction is the phenomenon of formation of non-healing skin lesions or ulcers following minor injuries. Although conceptually similar to the isomorphic reaction (Koebnerisation), these are two separate phenomena that should be distinguishable to treating clinicians. The underlying pathomech...
| Publicado en: | Wound Practice & Research Vol. 30; no. 1; pp. 55 - 62 |
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| Autores principales: | , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Cambridge Publishing
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | Pathergy reaction is the phenomenon of formation of non-healing skin lesions or ulcers following minor injuries. Although conceptually similar to the isomorphic reaction (Koebnerisation), these are two separate phenomena that should be distinguishable to treating clinicians. The underlying pathomechanisms of pathergy are not yet fully understood and subsequently therapy is lacking. Recent advances in the understanding of wound healing through keratinocyte and fibroblast cross-talk and mesenchymal stem cell (MSC) may hopefully foster the development of novel targeted therapies for pathergy-associated wounds and diseases in the near future. |
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