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Pathergy: a review of potential mechanisms and novel therapeutic targets.

Pathergy reaction is the phenomenon of formation of non-healing skin lesions or ulcers following minor injuries. Although conceptually similar to the isomorphic reaction (Koebnerisation), these are two separate phenomena that should be distinguishable to treating clinicians. The underlying pathomech...

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Published in:Wound Practice & Research Vol. 30; no. 1; pp. 55 - 62
Main Authors: Honigman, Anthony, Kern, Johannes S., Frew, John W.
Format: pictorial review tables/charts Journal Article
Published: Cambridge Publishing Mar2022
Online Access:View this record in EBSCOhost
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      dt: Mar2022
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      pub: Cambridge Publishing
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        10.33235/wpr.30.1.55-61
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        atl: Pathergy: a review of potential mechanisms and novel therapeutic targets.
      aug:
        au:
          Honigman, Anthony
          Kern, Johannes S.
          Frew, John W.
        affil: Dermatology Department, The Royal Melbourne Hospital, Melbourne, VIC, Australia
      sug:
        subj:
          Behcet's Syndrome Diagnosis
          Behcet's Syndrome Therapy
          Behcet's Syndrome Physiopathology
          Wounds and Injuries Complications
          Phenomenology
          Wound Care
          Wound Healing
          Mesenchymal Stem Cells
      ab: Pathergy reaction is the phenomenon of formation of non-healing skin lesions or ulcers following minor injuries. Although conceptually similar to the isomorphic reaction (Koebnerisation), these are two separate phenomena that should be distinguishable to treating clinicians. The underlying pathomechanisms of pathergy are not yet fully understood and subsequently therapy is lacking. Recent advances in the understanding of wound healing through keratinocyte and fibroblast cross-talk and mesenchymal stem cell (MSC) may hopefully foster the development of novel targeted therapies for pathergy-associated wounds and diseases in the near future.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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