Docosahexaenoic Acid in the Inhibition of Tumor Cell Growth in Preclinical Models of Ovarian Cancer.
There is a strong rationale for investigating nutritional interventions with docosahexaenoic acid (DHA) in cancer prevention and therapy; however, the effects of DHA on ovarian cancer (OC) have not been well studied. Here, we investigated if DHA alone and in combination with carboplatin reduces OC c...
| Publicado en: | Nutrition & Cancer Vol. 74; no. 4; pp. 1431 - 1446 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=156475258&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 156475258 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2022 vid: 74 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 156475258 151513299 156475258 156475258 10.1080/01635581.2021.1952453 156475258 ppf: 1431 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Docosahexaenoic Acid in the Inhibition of Tumor Cell Growth in Preclinical Models of Ovarian Cancer. aug: au: Bilyk, Olena Hamedi, Bahareh Dutta, Indrani Newell, Marnie Bukhari, Amirali B. Gamper, Armin M. McVea, Rojine C. Liu, Jiahui Schueler, Julia Siegers, Gabrielle M. Field, Catherine J. Postovit, Lynne-Marie affil: Department of Experimental Oncology, University of Alberta, Edmonton, Alberta, Canada sug: subj: Docosahexaenoic Acids Therapeutic Use Ovarian Neoplasms Drug Therapy Growth Inhibitors Drug Effects Docosahexaenoic Acids Pharmacodynamics Animal Studies Mice In Vivo Studies Carboplatin Therapeutic Use Descriptive Statistics Diet Apoptosis In Vitro Studies Xenografts Antineoplastic Agents, Combined Therapeutic Use Drug Synergism Dietary Supplementation Comparative Studies ab: There is a strong rationale for investigating nutritional interventions with docosahexaenoic acid (DHA) in cancer prevention and therapy; however, the effects of DHA on ovarian cancer (OC) have not been well studied. Here, we investigated if DHA alone and in combination with carboplatin reduces OC cell growth in vitro. In vivo, we used a high-grade serous OC patient-derived xenograft (PDX) mouse model to investigate if DHA affects OC growth and enhances the anticancer actions of carboplatin. We showed synergistic cell killing by DHA and carboplatin in DHA-resistant Kuramochi and SKOV3 OC cells, which corresponded with increased DHA incorporation into whole-cell membrane phospholipids (P < 0.05). In vivo, feeding mice a diet supplemented with 3.9% (w/w of fat) DHA resulted in a significant reduction in PDX growth with and without carboplatin (P < 0.05). This reduction in tumor growth was accompanied by an increased tumor necrotic region (P < 0.05) and improved survival. Plasma membranes in tumors and livers excised from mice fed a DHA diet had ∼ twofold increase in DHA incorporation as compared with mice fed a control diet. Our findings indicate that DHA supplementation reduces cancer cell growth and enhances the efficacy of carboplatin in preclinical models of OC through increased apoptosis and necrosis. Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1952453 pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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