Oxidative Stress Mediates the Association Between Dietary Fat Intake and Cognition in US Older Adults.
Objective: Dietary fat intake was considered as a modifiable factor influencing cognitive performance. The objective was to 1) examine the associations between different types of dietary fat intakes and cognitive outcomes among elder adults (≥60 years old); 2) assess whether peripheral oxidative str...
| Publicado en: | American Journal of Geriatric Psychiatry Vol. 30; no. 7; pp. 761 - 774 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jul2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=157219994&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 157219994 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10647481 GIF jtl: American Journal of Geriatric Psychiatry issn: 10647481 maglogo: N pubinfo: dt: Jul2022 vid: 30 iid: 7 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 157219994 157219994 NLM35151552 157219994 10.1016/j.jagp.2022.01.001 NLM35151552 157219994 ppf: 761 ppct: 13 formats: tig: atl: Oxidative Stress Mediates the Association Between Dietary Fat Intake and Cognition in US Older Adults. aug: au: Liu, Dan Zhou, Long Yang, Ming McIntyre, Roger S. Cao, Bing affil: Population Health Sciences (DL), German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany sug: subj: Antioxidants Uric Acid Cross Sectional Studies Dietary Fats Cognition Surveys Animals Oxidative Stress Aged Aged: 65+ years ab: Objective: Dietary fat intake was considered as a modifiable factor influencing cognitive performance. The objective was to 1) examine the associations between different types of dietary fat intakes and cognitive outcomes among elder adults (≥60 years old); 2) assess whether peripheral oxidative stress and antioxidant biomarkers are potential mediators of dietary fat intake and cognitive impairment relationship.Methods: Using data from National Health and Nutrition Examination Survey 2011-2014, total fat, saturated fatty acid (SFAT), monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), cholesterol, ω-3 and ω-6 fatty acids were used to evaluate dietary fat intakes. Cognitive outcomes were assessed by word learning and recall modules from the consortium to establish a registry for Alzheimer's Disease (CERAD), animal fluency test, and digit symbol substitution test (DSST). Antioxidant biomarkers were assessed by gamma glutamyl transpeptidase (GGT), bilirubin, uric acid, and vitamin D levels. Linear regression models and causal mediation analysis were applied to quantify the associations.Results: A total of 2,253 elder adults were included in the data analyses. Dietary intake of PUFA and ω-6 fatty acid were positively associated with DSST [β (95% CI): 0.06 (0.01,0.10), t statistic = 2.39, df= 2238, p = 0.02; β (95% CI): 0.06 (0.01,0.11), t statistic = 2.54, df= 2238, p = 0.01, respectively]. GGT was negatively associated with DSST [β (95% CI): -0.04 (-0.07, -0.01), t statistic = -2.73, df= 2239, p = 0.01], whereas uric acid was positively associated with CERAD total score [β (95% CI): 0.04 (0.00,0.08), t statistic = 2.03, df= 2233, p = 0.04]. The association between dietary intake of PUFA/ω -3/ω -6 and DSST performance was partially mediated by GGT level.Conclusion: Our findings support that PUFAs in dietary sources were associated with lower risks for cognitive impairment partially via lowering oxidative stress. Dietary PUFA supplementation may potentially reduce risk of cognitive impairment via antioxidative mechanism. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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