Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.

Rationale: Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. Objective: Our goal was to characterize the acute and chronic effect...

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Bibliographic Details

Published in:	Psychopharmacology Vol. 239; no. 8; pp. 2457 - 2471
Main Authors:	Straathof, Milou, Blezer, Erwin L. A., Smeele, Christel E., van Heijningen, Caroline, van der Toorn, Annette, Buitelaar, Jan K., Glennon, Jeffrey C., Otte, Willem M., Dijkhuizen, Rick M., TACTICS Consortium, Buitelaar, Jan, de Ruiter, Saskia, Naaijen, Jilly, Akkermans, Sophie, Mennes, Maarten, Zwiers, Marcel, Ilbegi, Shahrzad, Hennissen, Leonie, Glennon, Jeffrey, van de Vondervoort, Ilse
Format:	Journal Article
Published:	Springer Nature Aug2022
Online Access:	View this record in EBSCOhost