Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.

Rationale: Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. Objective: Our goal was to characterize the acute and chronic effect...

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Publicado en:	Psychopharmacology Vol. 239; no. 8; pp. 2457 - 2471
Autores principales:	Straathof, Milou, Blezer, Erwin L. A., Smeele, Christel E., van Heijningen, Caroline, van der Toorn, Annette, Buitelaar, Jan K., Glennon, Jeffrey C., Otte, Willem M., Dijkhuizen, Rick M., TACTICS Consortium, Buitelaar, Jan, de Ruiter, Saskia, Naaijen, Jilly, Akkermans, Sophie, Mennes, Maarten, Zwiers, Marcel, Ilbegi, Shahrzad, Hennissen, Leonie, Glennon, Jeffrey, van de Vondervoort, Ilse
Formato:	Journal Article
Publicado:	Springer Nature Aug2022
Acceso en línea:	Ver este registro en EBSCOhost