| Sumario: | Background: Whether a history of mild traumatic brain injury (mTBI) affects pupil dynamics that could confound the interpretation of pupil data in other causes of visual dysfunction is unknown. We investigated the relationship between history of mTBI and pupil dynamics recorded with highdefinition pupillography. Methods:Subjects (n = 137) aged 19 to 81 years were enrolled from attendees of an optometric meeting in 2016. The data collected included: ocular and systemic health histories, current medications, history of TBI, and pupil dynamics using the automated afferent pupillary defect protocol of the RAPDx (Konan Medical). Multiple regressions with backward analysis were used to identify factors that predicted pupil dynamics. Results: Thirty-five subjects reported positive history of mTBI (15 reported more than 1 mTBI). None of the pupil parameters assessed for either eye were predicted by history of mTBI. Time from most recent head injury to pupil testing predicted only latency of constriction onset of each eye (right eye: P = 0.02, R2 = 0.214; left eye: P = 0.02, R2 = 0.187). Age and time from most recent head injury to pupil testing predicted latency of constriction onset for each eye in those reporting head injury (right eye: adjusted R2 = 0.23, P = 0.02; left eye: adjusted R2 = 0.26, P = 0.01). Conclusions: Dynamic pupil parameters elicited with a bright white stimulus were not predicted by history of mTBI. Time from most recent mTBI to date of pupil testing may partially predict latency of pupil constriction, and longer times from most recent mTBI to date of pupil testing may be associated with slower redilation velocities. However, the influence of age on the association between time from most recent mTBI and velocity of redilation in this study sample is unknown.
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