COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls.

Background: Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described. Methods: We reviewed the published cases of COVID-19-associated Cryptococcus infection...

Descripción completa

Detalles Bibliográficos
Publicado en:Infection Vol. 50; no. 4; pp. 1007 - 1013
Autores principales: Regalla, Dinesh, VanNatta, Mollie, Alam, Mohammad, Malek, Alexandre E.
Formato: review tables/charts Journal Article
Publicado: Springer Nature Aug2022
Acceso en línea:Ver este registro en EBSCOhost
Descripción
Sumario:Background: Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described. Methods: We reviewed the published cases of COVID-19-associated Cryptococcus infections (CACI) to shed the light on the burden of this infection. Results: We identified 13 patients with confirmed cryptococcal infection. Cryptococcus infection was primarily seen in patients with severe COVID-19 disease who received corticosteroids therapy and admitted to the intensive care unit. Pulmonary CACI was the most common reported infection followed by cryptococcal meningitis. Conclusion: In light of the high mortality rate, clinicians should maintain a high clinical suspicion of CACI in critically ill patients.