COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls.

Background: Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described. Methods: We reviewed the published cases of COVID-19-associated Cryptococcus infection...

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Publicado en:Infection Vol. 50; no. 4; pp. 1007 - 1013
Autores principales: Regalla, Dinesh, VanNatta, Mollie, Alam, Mohammad, Malek, Alexandre E.
Formato: review tables/charts Journal Article
Publicado: Springer Nature Aug2022
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s15010-022-01805-y
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        atl: COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls.
      aug:
        au:
          Regalla, Dinesh
          VanNatta, Mollie
          Alam, Mohammad
          Malek, Alexandre E.
        affil: Division of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA
      sug:
        subj:
          COVID-19 Complications
          Cryptococcosis Etiology
          Immunosuppression
          Opportunistic Infections
          Severity of Illness Adverse Effects
          COVID-19 Drug Therapy
          Adrenal Cortex Hormones
          Patient Admission
          Intensive Care Units
          Lung Diseases, Fungal
          Meningitis, Cryptococcal
          Critically Ill Patients
          Cryptococcosis Prognosis
          Cryptococcosis Epidemiology
          Cryptococcosis Risk Factors
          Risk Assessment
      ab: Background: Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described. Methods: We reviewed the published cases of COVID-19-associated Cryptococcus infections (CACI) to shed the light on the burden of this infection. Results: We identified 13 patients with confirmed cryptococcal infection. Cryptococcus infection was primarily seen in patients with severe COVID-19 disease who received corticosteroids therapy and admitted to the intensive care unit. Pulmonary CACI was the most common reported infection followed by cryptococcal meningitis. Conclusion: In light of the high mortality rate, clinicians should maintain a high clinical suspicion of CACI in critically ill patients.
      pubtype: Academic Journal
      doctype:
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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