| Sumario: | Purpose: This study aimed to determine the effectiveness of mindfulness‐based mandala activity on the anxiety levels and spiritual well‐being of nursing students who started clinical practice after distance education during COVID‐19 period. Design and Methods: This study is a randomized controlled study employing a pre‐/posttest design with a single‐blind, parallel group. The study was completed with a total of 170 participants (n = 84, intervention group; n = 86, control group). Data were collected using the Descriptive Characteristics Form, State‐trait Anxiety Inventory, Spirituality Well‐Being Scale, and Scale of Positive and Negative Experience. The intervention group participated in three mindfulness‐based mandala sessions. This study was registered with ClinicalTrials.gov as NCT05053178. Findings: In three sessions, there was a significant decrease in the intervention group compared with the control group regarding the mean values of pretest and posttest anxiety levels. Evaluation of the mean scores Spiritual Well‐Being Scale before and after the intervention showed a significant decrease in the scores between groups (p < 0.05). Practice Implications: With mindfulness‐based mandala activity, the well‐being of nursing students can be increased.
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