Chemical Confirmation of a Pentavalent Phosphorane in Complex with β-Phosphoglucomutase.
The article focuses on a study related to chemical confirmation of a pentavalent phosphorane in complex with β-phosphoglucomutase. The catalytic power of enzymes originates from their ability to stabilize high-energy transition states and intermediates. Results validate original assignment of the β-...
| Publicado en: | Journal of the American Chemical Society Vol. 127; no. 15; pp. 5298 - 5300 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
4/20/2005
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | The article focuses on a study related to chemical confirmation of a pentavalent phosphorane in complex with β-phosphoglucomutase. The catalytic power of enzymes originates from their ability to stabilize high-energy transition states and intermediates. Results validate original assignment of the β-PGM-βD-glucose-6-phosphate-1-phosphorane complex to the previously reported X-ray diffraction data. Dataset and protein model phases only shows electron density of identical magnitude for both atoms assigned as phosphorus. |
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