Structural Dynamics of P-Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis.

Phosphatidylinositol 3,4,5-trisphosphate- (PIP3-) dependent Rac exchanger 1 (P-Rex1) functions as Rho guanine nucleotide exchange factor and is activated by synergistic activity of Gβγ and PIP3 of the heterotrimeric G protein. P-Rex1 activates Rac GTPases for regulating cell invasion and migration a...

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Bibliographic Details

Published in:	BioMed Research International pp. 1 - 17
Main Authors:	Hameed, Alaa R., Ali, Sama Fakhri, Alsallameh, Sarah M. S., Muhseen, Ziyad Tariq, Almansour, Nahlah Makki, ALSuhaymi, Naif, Alsugoor, Mahdi H., Allemailem, Khaled S.
Format:	research Journal Article
Published:	Wiley-Blackwell 12/7/2023
Online Access:	View this record in EBSCOhost