Structural Dynamics of P-Rex1 Complexed with Natural Leads Establishes the Protein as an Attractive Target for Therapeutics to Suppress Cancer Metastasis.

Phosphatidylinositol 3,4,5-trisphosphate- (PIP3-) dependent Rac exchanger 1 (P-Rex1) functions as Rho guanine nucleotide exchange factor and is activated by synergistic activity of Gβγ and PIP3 of the heterotrimeric G protein. P-Rex1 activates Rac GTPases for regulating cell invasion and migration a...

Descripción completa

Detalles Bibliográficos

Publicado en:	BioMed Research International pp. 1 - 17
Autores principales:	Hameed, Alaa R., Ali, Sama Fakhri, Alsallameh, Sarah M. S., Muhseen, Ziyad Tariq, Almansour, Nahlah Makki, ALSuhaymi, Naif, Alsugoor, Mahdi H., Allemailem, Khaled S.
Formato:	research Journal Article
Publicado:	Wiley-Blackwell 12/7/2023
Acceso en línea:	Ver este registro en EBSCOhost