| Sumario: | Aims: To test how attentional bias and explicit liking are influenced by delta‐9‐tetrahydrocannabinol (THC) and whether these effects are moderated by cannabidiol (CBD). Design: Double‐blind, randomised, within‐subjects cross‐over study. Setting NIHR Wellcome Trust Clinical Research Facility at King's College Hospital, London, United Kingdom. Participants/Cases: Forty‐six infrequent cannabis users (cannabis use <1 per week). Intervention(s): Across four sessions, participants inhaled vaporised cannabis containing 10 mg of THC and either 0 mg (0:1 CBD:THC), 10 mg (1:1), 20 mg (2:1) or 30 mg (3:1) of CBD, administered in a randomised order and counter‐balanced across participants (a total of 24 order groups). Measurements Participants completed two tasks: (1) Attentional Bias (AB), comparing reaction times toward visual probes presented behind 28 target stimuli (cannabis/food) compared with probes behind corresponding non‐target (neutral) stimuli. Participants responding more quickly to probes behind target than non‐target stimuli would indicate greater attentional bias to cannabis/food; (2) Picture Rating (PR), where all AB stimuli were rated on a 7‐point pleasantness scale, measuring explicit liking. Findings During the AB task, participants were more biased toward cannabis stimuli in the 0:1 condition compared with baseline (mean difference = 12.2, 95% confidence intervals [CIs] = 1.20–23.3, d = 0.41, P = 0.03). No other significant AB or PR differences were found between cannabis and food stimuli between baseline and 0:1 condition (P > 0.05). No significant CBD effect was found on AB or PR task performance at any dose (P > 0.05). There was additionally no cumulative effect of THC exposure on AB or PR outcomes (P > 0.05). Conclusions: A double‐blind, randomised, cross‐over study among infrequent cannabis users found that inhaled delta‐9‐tetrahydrocannabinol increased attentional bias toward cannabis in the absence of explicit liking, a marker of liability toward cannabis use disorder. At the concentrations normally found in legal and illegal cannabis, cannabidiol had no influence on this effect.
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