Cannabidiol does not attenuate acute delta‐9‐tetrahydrocannabinol‐induced attentional bias in healthy volunteers: A randomised, double‐blind, cross‐over study.
Aims: To test how attentional bias and explicit liking are influenced by delta‐9‐tetrahydrocannabinol (THC) and whether these effects are moderated by cannabidiol (CBD). Design: Double‐blind, randomised, within‐subjects cross‐over study. Setting NIHR Wellcome Trust Clinical Research Facility at King...
| Publicado en: | Addiction Vol. 119; no. 2; pp. 322 - 334 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=174713395&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 174713395 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Feb2024 vid: 119 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 174713395 172905342 174713395 174713395 10.1111/add.16353 174713395 ppf: 322 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Cannabidiol does not attenuate acute delta‐9‐tetrahydrocannabinol‐induced attentional bias in healthy volunteers: A randomised, double‐blind, cross‐over study. aug: au: Oliver, Dominic Englund, Amir Chesney, Edward Chester, Lucy Wilson, Jack Sovi, Simina Wigroth, Stina Hodsoll, John Strang, John Murray, Robin M. Freeman, Tom P. Fusar‐Poli, Paolo McGuire, Philip affil: Department of Psychiatry, University of Oxford, Oxford, UK sug: subj: Substance Use Disorders Chemically Induced Attentional Bias Evaluation Cannabis Adverse Effects Hydrocarbons Adverse Effects Cannabidiol Therapeutic Use Cannabidiol Pharmacodynamics Human Randomized Controlled Trials Double-Blind Studies Descriptive Statistics Data Analysis Software Male Female Young Adult Adult Cannabis Administration and Dosage Middle Age Odds Ratio Confidence Intervals Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Aims: To test how attentional bias and explicit liking are influenced by delta‐9‐tetrahydrocannabinol (THC) and whether these effects are moderated by cannabidiol (CBD). Design: Double‐blind, randomised, within‐subjects cross‐over study. Setting NIHR Wellcome Trust Clinical Research Facility at King's College Hospital, London, United Kingdom. Participants/Cases: Forty‐six infrequent cannabis users (cannabis use <1 per week). Intervention(s): Across four sessions, participants inhaled vaporised cannabis containing 10 mg of THC and either 0 mg (0:1 CBD:THC), 10 mg (1:1), 20 mg (2:1) or 30 mg (3:1) of CBD, administered in a randomised order and counter‐balanced across participants (a total of 24 order groups). Measurements Participants completed two tasks: (1) Attentional Bias (AB), comparing reaction times toward visual probes presented behind 28 target stimuli (cannabis/food) compared with probes behind corresponding non‐target (neutral) stimuli. Participants responding more quickly to probes behind target than non‐target stimuli would indicate greater attentional bias to cannabis/food; (2) Picture Rating (PR), where all AB stimuli were rated on a 7‐point pleasantness scale, measuring explicit liking. Findings During the AB task, participants were more biased toward cannabis stimuli in the 0:1 condition compared with baseline (mean difference = 12.2, 95% confidence intervals [CIs] = 1.20–23.3, d = 0.41, P = 0.03). No other significant AB or PR differences were found between cannabis and food stimuli between baseline and 0:1 condition (P > 0.05). No significant CBD effect was found on AB or PR task performance at any dose (P > 0.05). There was additionally no cumulative effect of THC exposure on AB or PR outcomes (P > 0.05). Conclusions: A double‐blind, randomised, cross‐over study among infrequent cannabis users found that inhaled delta‐9‐tetrahydrocannabinol increased attentional bias toward cannabis in the absence of explicit liking, a marker of liability toward cannabis use disorder. At the concentrations normally found in legal and illegal cannabis, cannabidiol had no influence on this effect. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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