Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis.
Purpose: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Our study included 450,111...
| Publicado en: | European Journal of Nutrition Vol. 63; no. 2; pp. 377 - 397 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=175695763&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 175695763 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2024 vid: 63 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 175695763 173736930 175695763 175695763 10.1007/s00394-023-03270-1 175695763 ppf: 377 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. aug: au: Morales-Berstein, Fernanda Biessy, Carine Viallon, Vivian Goncalves-Soares, Ana Casagrande, Corinne Hémon, Bertrand Kliemann, Nathalie Cairat, Manon Blanco Lopez, Jessica Al Nahas, Aline Chang, Kiara Vamos, Eszter Rauber, Fernanda Bertazzi Levy, Renata Barbosa Cunha, Diana Jakszyn, Paula Ferrari, Pietro Vineis, Paolo Masala, Giovanna Catalano, Alberto affil: MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK sug: subj: Food Intake Food, Commercially Packaged Adverse Effects Adipose Tissue Distribution Esophageal Neoplasms Risk Factors Adenocarcinoma Risk Factors Head and Neck Neoplasms Risk Factors Risk Assessment Human Male Female Mediation Analysis Europe Prospective Studies Cox Proportional Hazards Model Descriptive Statistics Comparative Studies Body Mass Index Waist-Hip Ratio Alcohol Drinking Physical Activity Educational Status Data Analysis Software Funding Source Confidence Intervals Fast Foods Male Female ab: Purpose: To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome. Results: During a mean follow-up of 14.13 ± 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14–1.34) and OAC (HR = 1.24, 95% CI 1.05–1.47). WHR mediated 5% (95% CI 3–10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6–53%) and 15% (95% CI 8–72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis. Conclusions: We reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers). pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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