Oil-Based Curcuminoid Phospholipid Formulation Mimicking Natural Digestion Enhances Oral Bioavailability of Curcuminoids in Healthy Subjects.
Curcumin, the fat-soluble active ingredient and major compound of curcuminoids contained in the curcuma root, is known for its physiological low absorption and bioavailability. Various formulations and galenic technologies are currently available on the market. In this study, the product tested was...
| Publicado en: | Journal of Medicinal Food Vol. 27; no. 5; pp. 396 - 404 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
May2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=177560906&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 177560906 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1096620X C1S jtl: Journal of Medicinal Food issn: 1096620X maglogo: N pubinfo: dt: May2024 vid: 27 iid: 5 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 177560906 177560906 177560906 10.1089/jmf.2023.0185 177560906 ppf: 396 ppct: 8 formats: tig: atl: Oil-Based Curcuminoid Phospholipid Formulation Mimicking Natural Digestion Enhances Oral Bioavailability of Curcuminoids in Healthy Subjects. aug: au: Wagner, Tanja Wacker, Roland Klein, Thomas Kompek, Albert Schön, Christiane affil: BioTeSys GmbH, Esslingen, Germany sug: subj: Oils Curcumin Administration and Dosage Phospholipids Administration and Dosage Chemistry, Pharmaceutical Digestion Mouth Biological Availability Capsules Administration and Dosage Plant Extracts Administration and Dosage Curcumin Pharmacokinetics Phospholipids Pharmacokinetics Plant Extracts Pharmacokinetics Human Randomized Controlled Trials Random Assignment Male Female Adult Crossover Design Administration, Oral Metabolites Comparative Studies Functional Food Plant Extracts Analysis Plant Extracts Blood Funding Source Liquid Chromatography-Mass Spectrometry Descriptive Statistics Data Analysis Software Confidence Intervals Wilcoxon Rank Sum Test Patient Safety Adult: 19-44 years Male Female ab: Curcumin, the fat-soluble active ingredient and major compound of curcuminoids contained in the curcuma root, is known for its physiological low absorption and bioavailability. Various formulations and galenic technologies are currently available on the market. In this study, the product tested was provided as a soft gelatin capsule containing curcuminoids in an oily matrix mixed with phospholipids (oil/phospholipids [PL]-based, no new technologies applied or artificial excipients added). This was intended to improve bioavailability of curcuminoids as well as to mimic the natural digestion process of fat-soluble substances. In particular, the oral bioavailability of curcuminoids in the oil/PL-based formulation was compared with the pure curcuminoids extract alone (reference product), in a randomized, cross-over, single oral dose study design. Twelve healthy subjects were administered 200 mg curcuminoids under fasting conditions. Pharmacokinetic parameters were analyzed from individual concentration–time curves of total curcuminoids, as well as the curcumin metabolite tetrahydrocurcumin (THC). Results showed significantly higher AUC0-8h levels after the intake of the oil/PL-based formulation for total curcuminoids (205.60 vs. 112.50 ng/mL*h, P =.0001) as well as for THC (347.30 vs. 118.90 ng/mL*h, P <.0001) in comparison to the pure curcuminoids extract. Cmax was also significantly higher for both parameters analyzed (total curcuminoids: 47.54 vs. 21.16 ng/mL, P =.0001; THC: 96.69 vs. 29.83 ng/mL, P <.0001). In addition, the uptake kinetic of total curcuminoids was significantly fastened with the oil/PL-based curcuminoids formulation compared with the pure curcuminoids extract (P =.0446). These data suggest an improved impact on curcuminoids uptake of the oil/PL-based formulation and confirms its good tolerability. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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