| Sumario: | Background In 1937, oral phenytoin medication was introduced as an anti-epileptic drug. For many years, researchers have shown interest in how topical phenytoin may be used to promote wound healing in various wounds. Purpose This review article aims to summarise and critically appraise the clinical evidence available on the effects of topical phenytoin on wound healing. Methods By using the keywords phenytoin, injuries, wound, wound care, and wound healing, we extracted articles published up to April 2022 through a search in PubMed, ISI Web of Science, SID, Google Scholar and Scopus. Result We identified 17 studies performed on human subjects and eight on rats. Phenytoin effectiveness is also compared with other wound care substances, including tretinoin, silver sulfadiazine, EUSOL, honey, dexamethasone and hypericin. Conclusion This review illustrated the significant effects and rare adverse events of topical phenytoin on wound healing.
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