Melatonin does not reduce delirium severity in hospitalized older adults: Results of a randomized placebo‐controlled trial.

Background: Delirium is common in older inpatients, causing distress, cognitive decline, and death. Current therapies are unsatisfactory, limited by lack of efficacy and adverse effects. There is an urgent need for effective delirium treatment. Sleep wake cycle is disturbed in delirium; endogenous M...

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Bibliographic Details
Published in:	Journal of the American Geriatrics Society Vol. 72; no. 6; pp. 1802 - 1810
Main Authors:	Lange, Peter W., Turbić, Alisa, Soh, Cheng Hwee, Clayton‐Chubb, Daniel, Lim, Wen Kwang, Conyers, Rachel, Watson, Rosie, Maier, Andrea B.
Format:	Article
Published:	Wiley-Blackwell Jun2024
Subjects:	Placebos Blind experiment Randomized controlled trials Hospital care of older people Old age Controlled release preparations Data analysis Research funding Statistical sampling Severity of illness index Melatonin Oral drug administration Treatment effectiveness Tertiary care Descriptive statistics Mann Whitney U Test Delirium Statistics Internal medicine Comparative studies Length of stay in hospitals Sleep quality Sleep disorders Drug tolerance
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