Improvement of functional dyspepsia with Suaeda salsa (L.) Pall via regulating brain-gut peptide and gut microbiota structure.
Purpose: The traditional Chinese herbal medicine Suaeda salsa (L.) Pall (S. salsa) with a digesting food effect was taken as the research object, and its chemical composition and action mechanism were explored. Methods: The chemical constituents of S. salsa were isolated and purified by column chrom...
| Publicado en: | European Journal of Nutrition Vol. 63; no. 5; pp. 1929 - 1945 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=179069420&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 179069420 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Aug2024 vid: 63 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 179069420 176984893 179069420 179069420 10.1007/s00394-024-03401-2 179069420 ppf: 1929 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Improvement of functional dyspepsia with Suaeda salsa (L.) Pall via regulating brain-gut peptide and gut microbiota structure. aug: au: Zhang, Wenjun Wang, Xueyu Yin, Shuanghui Wang, Ye Li, Yong Ding, Yuling affil: https://ror.org/035cyhw15 School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, 130117, Changchun, Jilin, China sug: subj: Dyspepsia Drug Therapy Drugs, Chinese Herbal Pharmacodynamics Brain-Gut Axis Drug Effects Gut Microbiota Drug Effects Peptides Drug Effects Animal Studies Mice Models, Biological Molecular Structure Descriptive Statistics Comparative Studies Gastrointestinal Motility Drug Effects Serotonin Magnetic Resonance Spectroscopy One-Way Analysis of Variance Funding Source ab: Purpose: The traditional Chinese herbal medicine Suaeda salsa (L.) Pall (S. salsa) with a digesting food effect was taken as the research object, and its chemical composition and action mechanism were explored. Methods: The chemical constituents of S. salsa were isolated and purified by column chromatography, and their structures were characterized by nuclear magnetic resonance. The food accumulation model in mice was established, and the changes of the aqueous extract of S. salsa in gastric emptying and intestinal propulsion rate, colonic tissue lesions, serum brain-gut peptide hormone, colonic tissue protein expression, and gut microbiota structure were compared. Results: Ten compounds were isolated from S. salsa named as naringenin (1), hesperetin (2), baicalein (3), luteolin (4), isorhamnetin (5), taxifolin (6), isorhamnetin-3-O-β-d-glucoside (7), luteolin-3′-d-glucuronide (8), luteolin-7-O-β-d-glucuronide (9), and quercetin-3-O-β-d-glucuronide (10), respectively. The aqueous extract of S. salsa can improve the pathological changes of the mice colon and intestinal peristalsis by increasing the rate of gastric emptying and intestinal propulsion. By adjusting the levels of 5-HT, CCK, NT, SS, VIP, GT-17, CHE, MTL, and ghrelin, it can upregulate the levels of c-kit, SCF, and GHRL protein, and restore the imbalanced structure of gut microbiota, further achieve the purpose of treating the syndrome of indigestion. The effect is better with the increase of dose. Conclusion: S. salsa has a certain therapeutic effect on mice with the syndrome of indigestion. From the perspective of "brain-gut-gut microbiota", the mechanism of digestion and accumulation of S. salsa was discussed for the first time, which provided an experimental basis for further exploring the material basis of S. salsa. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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