| Sumario: | This article presents information on human serum transferrin (Tf) that holds a central place in the metabolism of Fe(III). Tf also binds other metal ions. The binding strength correlates with the acidity of the metal. Of the few ions predicted to bind more tightly than Fe(III), only Bi(III) has been investigated, and its binding is weaker, probably because of its large size. Titanium(IV) is nearly the same size as Fe(III) and is a stronger hard Lewis acid. Titanium(IV) binding to transferrin is implicated in the bioactivity of Titanium-containing anticancer drugs and the plasma binding of Titanium from imaging reagents and implants.
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