Ti(IV) Binds to Human Serum Transferrin More Tightly Than Does Fe(III).
This article presents information on human serum transferrin (Tf) that holds a central place in the metabolism of Fe(III). Tf also binds other metal ions. The binding strength correlates with the acidity of the metal. Of the few ions predicted to bind more tightly than Fe(III), only Bi(III) has been...
| Publicado en: | Journal of the American Chemical Society Vol. 127; no. 32; pp. 11218 - 11220 |
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| Autores principales: | , |
| Formato: | Artículo |
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American Chemical Society
8/17/2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=18026704&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 18026704 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 8/17/2005 vid: 127 iid: 32 pid: 997 pub: American Chemical Society artinfo: ui: 18026704 10.1021/ja052768v ppf: 11218 ppct: 2 formats: tig: atl: Ti(IV) Binds to Human Serum Transferrin More Tightly Than Does Fe(III). aug: au: Tinoco, Arthur D. Valentine, Ann M. affil: Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107. su: Transferrin Serum Iron metabolism Electrons Titanium Ions Carrier proteins sug: subj: Transferrin Serum Iron metabolism Electrons Titanium Ions Carrier proteins ab: This article presents information on human serum transferrin (Tf) that holds a central place in the metabolism of Fe(III). Tf also binds other metal ions. The binding strength correlates with the acidity of the metal. Of the few ions predicted to bind more tightly than Fe(III), only Bi(III) has been investigated, and its binding is weaker, probably because of its large size. Titanium(IV) is nearly the same size as Fe(III) and is a stronger hard Lewis acid. Titanium(IV) binding to transferrin is implicated in the bioactivity of Titanium-containing anticancer drugs and the plasma binding of Titanium from imaging reagents and implants. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2005 holdings: @attributes: islocal: N |
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