Radical Hydroxyalkylation of C-H Bond Adjacent to Nitrogen of Tertiary Amides, Ureas, and Amines.
The article discusses radical hydroxyalkylation of carbon-hydrogen (C-H) bond adjacent to Nitrogen of tertiary amides, ureas and amines. The authors show that several tertiary amides, ureas, and amines undergo direct intermolecular addition to aldehydes under the EtB/air conditions, thereby providin...
| Publicado en: | Journal of the American Chemical Society Vol. 127; no. 33; pp. 11610 - 11612 |
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| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
8/24/2005
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | The article discusses radical hydroxyalkylation of carbon-hydrogen (C-H) bond adjacent to Nitrogen of tertiary amides, ureas and amines. The authors show that several tertiary amides, ureas, and amines undergo direct intermolecular addition to aldehydes under the EtB/air conditions, thereby providing a unique and simple means for the radical sp C-H transformation of nitrogen-containing molecules. The amounts of C-H substrate and EtB influenced the efficiency of the reaction. |
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