Polymerase Evolution: Efforts toward Expansion of the Genetic Code.
This article focuses on a study related to polymerase evolution. Expansion of the alphabet to contain a third base pair would allow additional information to be encoded in DNA and would also enable a variety of in vitro experiments using unnatural nucleic acids. One strategy for improving the replic...
| Publicado en: | Journal of the American Chemical Society Vol. 127; no. 36; pp. 12470 - 12472 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Chemical Society
9/14/2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=18276039&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 18276039 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 9/14/2005 vid: 127 iid: 36 pid: 997 pub: American Chemical Society artinfo: ui: 18276039 10.1021/ja053322h ppf: 12470 ppct: 2 formats: tig: atl: Polymerase Evolution: Efforts toward Expansion of the Genetic Code. aug: au: Leconte, Aaron M. Chen, Liangjing Romesberg, Floyd E. affil: Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037. su: Nucleic acids DNA Polymerase chain reaction Biomolecules DNA replication Research sug: subj: Nucleic acids DNA Polymerase chain reaction Biomolecules DNA replication Research ab: This article focuses on a study related to polymerase evolution. Expansion of the alphabet to contain a third base pair would allow additional information to be encoded in DNA and would also enable a variety of in vitro experiments using unnatural nucleic acids. One strategy for improving the replication of these unnatural base pairs is based on their further derivatization with heteroatoms or alkyl substituents. This strategy mimics the optimization of the natural bases in nature. To optimize the replication of DNA containing PICS, researchers decided to select for variants of Sf that more efficiently synthesize and extend a primer-template terminus containing the self-pair. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2005 holdings: @attributes: islocal: N |
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