| Sumario: | Three new phthalide derivatives, denominated Cajanthalides A, B and C (1 – 3), were identified from the leaves of Cajanus cajan. Their structures were meticulously elucidated through comprehensive analysis utilizing UV, IR, NMR (1D and 2D), HRESIMS, chiral analysis and DP4+ analysis. Notably, these new phthalide derivatives are present in racemic forms, with compounds 2 and 3 sharing identical planar structures. A plausible biogenetic pathway is proposed to account for the biosynthesis of compounds 1 – 3. Biological evaluation revealed that compound 2 exhibited moderate antifungal activity against C. neoformans , C. albicans and M. furfur with MIC values of 40 μg/mL. [Display omitted] • Three undescribed phthalide derivatives were isolated from Cajanus. cajan with structures elucidated. • All these phthalide derivatives were determined to be mixtures of racematic pairs by chiral analysis. • A plausible biogenetic pathway of compounds 1 – 3 is proposed. • Compound 2 exhibited antifungal activity against C. neoformans , C. albicans and M. furfur with MIC values of 40 μg/mL.
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