Three new antifungal phthalide derivatives from Cajanus cajan.
Three new phthalide derivatives, denominated Cajanthalides A, B and C (1 – 3), were identified from the leaves of Cajanus cajan. Their structures were meticulously elucidated through comprehensive analysis utilizing UV, IR, NMR (1D and 2D), HRESIMS, chiral analysis and DP4+ analysis. Notably, these...
| Publicado en: | Fitoterapia Vol. 182 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Apr2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184036575&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184036575 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Apr2025 vid: 182 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 184036575 184036575 184036575 10.1016/j.fitote.2025.106462 184036575 ppct: 1 formats: tig: atl: Three new antifungal phthalide derivatives from Cajanus cajan. aug: au: Yao, Liyuan Jumai, Aikebaier Li, Xiancai Chen, Shaohua Li, Bailin Qiu, Sheng-Xiang affil: Program for Natural Product Chemical Biology, State Key Laboratory of Plant Diversity and Specialty Crops & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China sug: subj: Plant Extracts Analysis Antifungal Agents Analysis Plants, Medicinal Human Plant Leaves Magnetic Resonance Spectroscopy Methods Models, Biological Candida Albicans Drug Effects Cryptococcus Drug Effects Yeasts Drug Effects ab: Three new phthalide derivatives, denominated Cajanthalides A, B and C (1 – 3), were identified from the leaves of Cajanus cajan. Their structures were meticulously elucidated through comprehensive analysis utilizing UV, IR, NMR (1D and 2D), HRESIMS, chiral analysis and DP4+ analysis. Notably, these new phthalide derivatives are present in racemic forms, with compounds 2 and 3 sharing identical planar structures. A plausible biogenetic pathway is proposed to account for the biosynthesis of compounds 1 – 3. Biological evaluation revealed that compound 2 exhibited moderate antifungal activity against C. neoformans , C. albicans and M. furfur with MIC values of 40 μg/mL. [Display omitted] • Three undescribed phthalide derivatives were isolated from Cajanus. cajan with structures elucidated. • All these phthalide derivatives were determined to be mixtures of racematic pairs by chiral analysis. • A plausible biogenetic pathway of compounds 1 – 3 is proposed. • Compound 2 exhibited antifungal activity against C. neoformans , C. albicans and M. furfur with MIC values of 40 μg/mL. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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