A Case of Multiple Primary Pulmonary Neuroendocrine Carcinoma with EML4-ALK Fusion Gene Positive.
Neuroendocrine carcinoma (NEC), a subtype of neuroendocrine tumors with high proliferative activity, is characterized by strong invasiveness and poor prognosis. This article reports a previously healthy female non-smoker who developed NEC occurring sequentially in different lobes of both lungs. The...
| Publicado en: | Chinese Journal of Lung Cancer Vol. 28; no. 3; pp. 230 - 237 |
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| Autores principales: | , , , |
| Formato: | case study diagnostic images pictorial Journal Article |
| Publicado: |
Chinese Journal of Lung Cancer
Mar2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184366724&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184366724 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10093419 9014 jtl: Chinese Journal of Lung Cancer issn: 10093419 maglogo: N pubinfo: dt: Mar2025 vid: 28 iid: 3 pid: 54191 pub: Chinese Journal of Lung Cancer artinfo: ui: 184366724 184366724 184366724 10.3779/j.issn.1009-3419.2025.102.10 184366724 ppf: 230 ppct: 7 formats: fmt: @attributes: type: P tig: atl: A Case of Multiple Primary Pulmonary Neuroendocrine Carcinoma with EML4-ALK Fusion Gene Positive. aug: au: Yin ZHANG Yue HOU Tianming ZHANG Hong WANG affil: Department of Pulmonary and Critical Care Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China sug: subj: Carcinoma, Neuroendocrine Diagnosis Carcinoma, Neuroendocrine Therapy Carcinoma, Small Cell Diagnosis Lung Neoplasms Diagnosis Carcinoma, Neuroendocrine Familial and Genetic Proteins Analysis Female Staining and Labeling Carcinoma, Neuroendocrine Pathology Sequence Analysis Immunohistochemistry Radiography, Thoracic Tomography, X-Ray Computed Positron Emission Tomography Computed Tomography Bronchoscopy Tyrosine Kinase Inhibitors Therapeutic Use Protein Kinase Inhibitors Therapeutic Use Treatment Outcomes Female ab: Neuroendocrine carcinoma (NEC), a subtype of neuroendocrine tumors with high proliferative activity, is characterized by strong invasiveness and poor prognosis. This article reports a previously healthy female non-smoker who developed NEC occurring sequentially in different lobes of both lungs. The lesions were pathologically diagnosed by hematoxylineosin (HE) staining as large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC), respectively. Nextgeneration sequencing (NGS) performed on both lesions revealed the presence of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase (EML4-ALK) fusion mutations in both lesions. Notably, the patient achieved a significant therapeutic response to ALK-tyrosine kinase inhibitors (TKIs) targeted therapy. pubtype: Academic Journal doctype: case study diagnostic images pictorial Journal Article ougenre: Article language: Chinese refInfo: holdings: @attributes: islocal: N |
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