A Case of Multiple Primary Pulmonary Neuroendocrine Carcinoma with EML4-ALK Fusion Gene Positive.
Neuroendocrine carcinoma (NEC), a subtype of neuroendocrine tumors with high proliferative activity, is characterized by strong invasiveness and poor prognosis. This article reports a previously healthy female non-smoker who developed NEC occurring sequentially in different lobes of both lungs. The...
| Published in: | Chinese Journal of Lung Cancer Vol. 28; no. 3; pp. 230 - 237 |
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| Main Authors: | , , , |
| Format: | case study diagnostic images pictorial Journal Article |
| Published: |
Chinese Journal of Lung Cancer
Mar2025
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| Online Access: | View this record in EBSCOhost |
| Summary: | Neuroendocrine carcinoma (NEC), a subtype of neuroendocrine tumors with high proliferative activity, is characterized by strong invasiveness and poor prognosis. This article reports a previously healthy female non-smoker who developed NEC occurring sequentially in different lobes of both lungs. The lesions were pathologically diagnosed by hematoxylineosin (HE) staining as large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC), respectively. Nextgeneration sequencing (NGS) performed on both lesions revealed the presence of echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase (EML4-ALK) fusion mutations in both lesions. Notably, the patient achieved a significant therapeutic response to ALK-tyrosine kinase inhibitors (TKIs) targeted therapy. |
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