Talidomida.
Thalidomide is a derivative of glutamic acid, synthesized in 1953 by Wilhem Kunz in the Chemie Grünenthal laboratories in Germany. It was used for the treatment of symptoms of pregnancy as a hypnotic, sedative and antiemetic during the first trimester of pregnancy. One year after its commercializati...
| Publicado en: | Dermatología Revista Mexicana Vol. 68; no. 6; pp. 779 - 795 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
| Publicado: |
Edicion y Farmacia S.A. de C.V.
Nov/Dec2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=184748260&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 184748260 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 01854038 ZZT jtl: Dermatología Revista Mexicana issn: 01854038 maglogo: N pubinfo: dt: Nov/Dec2024 vid: 68 iid: 6 pid: 20199 pub: Edicion y Farmacia S.A. de C.V. artinfo: ui: 184748260 10.24245/drm/bmu.v68i6.10191 ppf: 779 ppct: 16 formats: fmt: @attributes: type: P size: 2.3MB tig: atl: Talidomida. aug: au: Ugalde Trejo, Nora Ximena Navarrete Solís, Josefina Beirana Palencia, Angélica María Delgado Moreno, Karla Paola Aguirre González, Juan Daniel Pérez Arroyo, Martha Viridiana affil: Clínica Hospital A Constitución, ISSSTE, Monterrey, Nuevo Léon, México UMAE 25, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Léon, México Hospital General de Zona 6, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México sug: keyword: Dermatology Skin diseases Teratogens Thalidomide Tumor necrosis factor-alpha Dermatología Dermatology enfermedades de la piel factor de necrosis tumoral alfa Skin diseases Talidomida teratógenos Teratogens Thalidomide Tumor necrosis factor-alpha ab: Thalidomide is a derivative of glutamic acid, synthesized in 1953 by Wilhem Kunz in the Chemie Grünenthal laboratories in Germany. It was used for the treatment of symptoms of pregnancy as a hypnotic, sedative and antiemetic during the first trimester of pregnancy. One year after its commercialization, approximately 3000 dysmelias were registered worldwide. Although enigmatic, thalidomide-based treatment is currently used in various dermatological diseases due to its immunomodulatory, anti-inflammatory, antiangiogenic, and antifibrotic action; although its administration is limited by teratogenicity and the lack of uniformity in the reports of other adverse effects. La talidomida es un derivado del ácido glutámico, sintetizado en 1953 por Wilhem Kunz en los laboratorios Chemie Grünenthal de Alemania. Se administró para el tratamiento de molestias del embarazo como hipnótico, sedante y antiemético durante el primer trimestre del embarazo. Un año posterior a su comercialización, se registraron en todo el mundo aproximadamente 3000 dismelias. Aunque enigmático, el tratamiento con talidomida se prescribe hasta la actualidad contra diversas enfermedades dermatológicas debido a su acción inmunomoduladora, antiinflamatoria, antiangiogénica y antifibrótica; aunque su administración está limitada por la teratogenicidad y la falta de uniformidad en los reportes de otros efectos adversos. pubtype: Academic Journal doctype: Article src: R language: Spanish refInfo: copyright: @attributes: flag: Y custom: Copyright of Dermatología Revista Mexicana is the property of Edicion y Farmacia S.A. de C.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Dermatología Revista Mexicana holder: Edicion y Farmacia S.A. de C.V. dt: @attributes: year: 2024 holdings: @attributes: islocal: N |
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