Talidomida.
Thalidomide is a derivative of glutamic acid, synthesized in 1953 by Wilhem Kunz in the Chemie Grünenthal laboratories in Germany. It was used for the treatment of symptoms of pregnancy as a hypnotic, sedative and antiemetic during the first trimester of pregnancy. One year after its commercializati...
| Publicado en: | Dermatología Revista Mexicana Vol. 68; no. 6; pp. 779 - 795 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | Artículo |
| Publicado: |
Edicion y Farmacia S.A. de C.V.
Nov/Dec2024
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | Thalidomide is a derivative of glutamic acid, synthesized in 1953 by Wilhem Kunz in the Chemie Grünenthal laboratories in Germany. It was used for the treatment of symptoms of pregnancy as a hypnotic, sedative and antiemetic during the first trimester of pregnancy. One year after its commercialization, approximately 3000 dysmelias were registered worldwide. Although enigmatic, thalidomide-based treatment is currently used in various dermatological diseases due to its immunomodulatory, anti-inflammatory, antiangiogenic, and antifibrotic action; although its administration is limited by teratogenicity and the lack of uniformity in the reports of other adverse effects. La talidomida es un derivado del ácido glutámico, sintetizado en 1953 por Wilhem Kunz en los laboratorios Chemie Grünenthal de Alemania. Se administró para el tratamiento de molestias del embarazo como hipnótico, sedante y antiemético durante el primer trimestre del embarazo. Un año posterior a su comercialización, se registraron en todo el mundo aproximadamente 3000 dismelias. Aunque enigmático, el tratamiento con talidomida se prescribe hasta la actualidad contra diversas enfermedades dermatológicas debido a su acción inmunomoduladora, antiinflamatoria, antiangiogénica y antifibrótica; aunque su administración está limitada por la teratogenicidad y la falta de uniformidad en los reportes de otros efectos adversos. |
|---|