Dietary inflammatory potential, genetic predisposition, and incidence of Crohn's disease and ulcerative colitis.
Background: Evidence for a potential link between dietary inflammatory potential and inflammatory bowel disease is limited, and the moderating role of genetic susceptibility remains to be assessed. Objective: To evaluate energy-adjusted dietary inflammatory index (E-DII) for the associations with in...
| Publicado en: | Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 12 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
5/1/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=184871690&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 184871690 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 5/1/2025 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 184871690 184871690 184871690 10.1186/s12986-025-00934-z 184871690 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dietary inflammatory potential, genetic predisposition, and incidence of Crohn's disease and ulcerative colitis. aug: au: Gu, Ji-Mei Zhao, Miao Zhu, Jie Tao, Hao-Wei Shao, Xiao-Ping Qin, Li-Qiang Ge, Yang-Yang Chen, Guo-Chong affil: https://ror.org/05t8y2r12 Department of Nutrition and Food Hygiene, School of Public Health, The Fourth Affiliated Hospital, Suzhou Medical College of Soochow University, 199 Ren'ai Road, 215123, Suzhou, China sug: subj: Crohn Disease Epidemiology Colitis, Ulcerative Epidemiology Disease Susceptibility Instrument Validation Risk Assessment Outcome Assessment Clinical Assessment Tools United Kingdom Human Male Female Adult Middle Age Aged Food Intake Multivariate Analysis Cox Proportional Hazards Model Regression Confidence Intervals Prospective Studies Descriptive Statistics Comparative Studies Genetic Risk Score UK Biobank Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Evidence for a potential link between dietary inflammatory potential and inflammatory bowel disease is limited, and the moderating role of genetic susceptibility remains to be assessed. Objective: To evaluate energy-adjusted dietary inflammatory index (E-DII) for the associations with incident Crohn's disease (CD) and ulcerative colitis (UC) and the role of genetic susceptibility. Methods: A total of 205,706 UK Biobank participants who were aged 39–72 years and had no known CD or UC at baseline (2006–2010) were included. The E-DII score was calculated based on energy-adjusted average intakes of 33 food or nutrient items derived from up to five 24-hour dietary recalls. Multivariable Cox regression models were used estimate hazard ratios (HRs) with 95% confidence interval (CI) for incident CD and UC. Results: During a median 12.3 years of follow-up, 382 incident CD and 798 incident UC cases were ascertained. A higher E-DII score was not associated with risk of CD (HR Q4 VS. Q1 = 1.28, 95% CI: 0.94–1.74; P-trend = 0.09) or UC (HR Q4 VS. Q1 = 1.10, 95% CI: 0.90–1.36; P-trend = 0.17). There was an interaction between the E-DII and the polygenic risk score (PRS) for CD on incident CD (P-interaction = 0.023), with an association only among participants with a high PRS (HR Q4 VS. Q1 = 1.64, 95% CI: 1.03–2.61) (P-interaction = 0.023). As compared with the participants with a low PRS for CD and a low E-DII score, participants with high levels of both scores had a particularly higher risk of CD (HR = 3.12; 95% CI: 1.74–5.60). Conclusions: The association of dietary inflammatory potential with incident CD appears to be amplified by high genetic susceptibility to CD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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