Thermal Equilibrium of High- and Low-Spin Forms of Cytochrome P450 BM-3: Repositioning of the Substrate?

We demonstrate that cytochrome P450 BM-3 in complex with N-palmitoylglycine undergoes a spin state change between room temperature, where optimal activity is seen, and low temperatures, where X-ray diffraction characterization has been carried out. On the basis of NMR measurements of the full-length...

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Publicado en:	Journal of the American Chemical Society Vol. 127; no. 39; pp. 13548 - 13553
Autores principales:	Jovanovic, Tijana, Farid, Ramy, Friesner, Richard A., McDermott, Ann E.
Formato:	Artículo
Publicado:	American Chemical Society 10/5/2005
Materias:	Cytochrome P-450 Thermal equilibrium Low temperatures Enzymes Optical diffraction Methodology
Acceso en línea:	Ver este registro en EBSCOhost