| Sumario: | Background/Objectives: Using chemical disinfectants to clean the base of heat-cured acrylic dentures has several negative effects, including toxicity. On the other hand, therapeutic herbs have fewer adverse effects. This study intended to determine how the antibacterial efficacy and the surface roughness of the heat-cured acrylic material used to fabricate dentures were affected by the use of Cordia myxa fruit (CMF) extract as a disinfection solution for dentures using the immersion technique. Methods: Heat-cured acrylic specimens were prepared (N = 110; 55 specimens) for each test; each group contained five specimens. Three CMF extract concentrations (50, 100, and 150 mg/mL) were made and examined for three immersion times (5, 10, and 15 min). The results were compared to the first control group, which used distilled water, and the second group, which used 2% glutaraldehyde for ten minutes, in accordance with the guidelines. One way analysis of variance ANOVA and Games–Howell post hoc test were employed in SPSS (Statistical Package for the Social Sciences) program for statistical analysis. Results: The results for the antibacterial test revealed that CMF solutions had a statistically significant difference in all test groups in comparison with the first control group and non-significant differences with (H p = 0.92; J p = 0.278; K p = 0.303) groups in comparison with the second control group (Glutaraldehyde 2%). For the surface roughness test, the effect was not statistically significant for all groups compared to the first and second control groups. Conclusions: It can be concluded that immersing the heat-cure acrylic samples in a solution of 100 mg/mL CMF extract for 15 min, and 150 mg/mL for 10 and 15 min, has an antibacterial effect similar to that of the Glutaraldehyde 2% antiseptic and no negative effect on surface roughness.
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