Multifaceted Applications of Synthesized Silver Nanoparticles From Marine Fungus Aspergillus flavus MK4: Antimicrobial, Anticancer, and Wound‐Healing Properties.

Due to their wide range of applications in modern technology, silver metallic nanomaterials have garnered considerable attention, driving significant research and development efforts. This study focuses on investigating the antimicrobial properties of silver nanoparticles (Ag‐NPs), encompassing thei...

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Publicado en:BioMed Research International Vol. 2025; pp. 1 - 18
Autores principales: Al-Agamy, Mohamed H., Kelany, Mahmoud S., Alshehri, Sultan, Alhuzani, Mohammad R., Hamed, Moaz M., Sabra, Wael, Mahdi, Wael A., Banerjee, Baisakhi
Formato: diagnostic images pictorial research tables/charts Journal Article
Publicado: Wiley-Blackwell 8/27/2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 8/27/2025
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1155/bmri/7161915
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        atl: Multifaceted Applications of Synthesized Silver Nanoparticles From Marine Fungus Aspergillus flavus MK4: Antimicrobial, Anticancer, and Wound‐Healing Properties.
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        au:
          Al-Agamy, Mohamed H.
          Kelany, Mahmoud S.
          Alshehri, Sultan
          Alhuzani, Mohammad R.
          Hamed, Moaz M.
          Sabra, Wael
          Mahdi, Wael A.
          Banerjee, Baisakhi
        affil: Department of Pharmaceutics,, College of Pharmacy,, King Saud University,, Riyadh, Saudi Arabia, ksu.edu.sa
      sug:
        subj:
          Fungi
          Aspergillus
          Nanoparticles
          Silver Compounds
          Antiinfective Agents
          Antineoplastic Agents
          Wound Healing Drug Effects
          Plant Extracts Analysis
          Plant Extracts Therapeutic Use
          Plant Extracts Pharmacodynamics
          Funding Source
          Human
          Descriptive Statistics
          Data Analysis Software
          Analysis of Variance
          Spectrum Analysis
          Biological Assay
          Cytotoxicity Tests, Immunologic
      ab: Due to their wide range of applications in modern technology, silver metallic nanomaterials have garnered considerable attention, driving significant research and development efforts. This study focuses on investigating the antimicrobial properties of silver nanoparticles (Ag‐NPs), encompassing their production, characterization, and biological aspects. The eco‐friendly extracellular biosynthetic method employed in this work utilizes extracts from the marine fungus Aspergillus flavus MK4 as reducing agents for nanoparticle synthesis. The analysis of colloidal Ag‐NPs using ultraviolet‐visible spectroscopy revealed a peak in absorbance at 460 nm, indicating the presence of plasmonic properties. Electron imaging of the internal structure (TEM) elucidated the spherical shape of Ag‐NPs, which measure 15 nm in size. Testing against bacterial diversities revealed potent antibacterial and antifungal efficacy. Cytotoxicity against the HepG‐2 cell line was assessed using the MTT assay, and antioxidant properties were examined through the radical scavenging (DPPH) assay. Based on their conceivable applications in the fields of antibacterial, anticancer, and wound healing, the synthesized Ag‐NPs exhibit promising features. With its powerful ability to synthesize Ag‐NPs, A. flavus MK4 can generate extensively characterized nanoparticles, demonstrating their antibacterial, antioxidant, anticancer, and wound‐healing properties.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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