Tau profiling across Alzheimer's disease staging reveals vulnerability to disease pathophysiology.
Background: Inter-individual variability in tau topography challenges the propagation hypothesis of tau aggregates. Methods: To address this gap, we propose the Manifold Component Analysis (MCA), for identifying pseudo-continuous profiles informed by the spatial continuity of stage regions. Results:...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 11; pp. 4281 - 4292 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187672845&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187672845 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Sep2025 vid: 52 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187672845 184693276 10.1007/s00259-025-07257-4 187672845 ppf: 4281 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Tau profiling across Alzheimer's disease staging reveals vulnerability to disease pathophysiology. aug: au: Bezgin, Gleb Pascoal, Tharick A. Therriault, Joseph Lussier, Firoza Z. Servaes, Stijn Kang, Min Su Savard, Mélissa Tissot, Cécile Stevenson, Jenna Wang, Yi-Ting Ottoy, Julie Rahmouni, Nesrine Fernandez-Arias, Jaime Hosseini, Seyyed Ali Aumont, Étienne Hall, Brandon Poltronetti, Nina Margherita Pallen, Vanessa Benedet, Andréa Lessa Ashton, Nicholas J. affil: https://ror.org/01pxwe438 Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada sug: ab: Background: Inter-individual variability in tau topography challenges the propagation hypothesis of tau aggregates. Methods: To address this gap, we propose the Manifold Component Analysis (MCA), for identifying pseudo-continuous profiles informed by the spatial continuity of stage regions. Results: Longitudinal and cross-sectional MCA in large aging cohort identified individual profiles (N = 753) expressing tau load in the entorhinal, limbic and neocortical regions. Using these profiles, we found neuropsychological and blood-based milestones of early and late disease stages. Finally, we also found evidence of rapid tau load increases and cognitive decline centered at the early-to-mid neocortical stages of Alzheimer's disease. Conclusions: Stage system based on tau load and spreading profiles across cortical areas provide a compelling framework for inferring pathophysiological prognosis in Alzheimer's disease. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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